Appointed director at MAMAC (Museum of Modern and Contemporary Art) in spring 2016, Hélène Guenin curated since then Gustav Metzger. Remember Nature (February 2017); A propos de Nice. 1947 – 1977 (Summer 2017); a survey show of Liz Magor (November 2017 – coproduction Migros Museum, Zurich; Kunstverein, Hamburg); Cosmogonies a multidisciplinary and historical group show focused on ecological issues and co-creation with Nature from Yves Klein to Thu-Van Tran; an exhibition focused on the interrelations between art and cinema in the 1960s: Le diable au corps. Quand l’Op art électrise le cinéma (Summer 2019 with Pauline Mari), and more recently, Lars Fredrikson with NMNM (with Rébecca François, 2019) ; and She-Bam Pow POP Wizz! The Amazons of POP (with Géraldine Gourbe, Oct 2020).Former chief curator at Centre Pompidou-Metz from 2008 to 2016, she developed there a multidisciplinary artistic program proposing a constant dialogue between the visual arts and the performing arts. She curated there, among others: Sublime. The tremors of the world; An Imaginary Museum with Tate Liverpool (Francesco Manacorda) and MMK Frankfurt (Peter Gorschlüter) ; Tania Mouraud. A Retrospective; Lines. A brief History; Wander – Labyrinthine variations with Guillaume Désanges. From 2002 to 2008 she was curator at Frac Lorraine and assistant curator at Casino Luxembourg – Forum d’art contemporain in 2001.